반응 #367466

반응 방정식

2,5,7-tribromo-3,4-dihydro-1(2H)-naphthalenone

imidazole

→

2-(1-imidazolyl)-3,4-dihydro-5,7-dibromo-1(2H)-naphthalenone

수율 62.1%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   기타The solvent was evaporated under reduced pressure
2. 2
   세척washed with H2O
3. 3
   추출was extracted with a solution of 8% HCl
4. 4
   추출extracted with CH2Cl2
5. 5
   기타dried
6. 6
   기타evaporated

실험 절차

A solution of 2,5,7-tribromo-3,4-dihydro-1(2H)-naphthalenone (1 g), imidazole (0.7 g), and N,N-dimethylformamide (15 ml) was stirred at room temperature for 5 hours. The solvent was evaporated under reduced pressure and the residue, taken up with CH2Cl2 (20 ml), washed with H2O, was extracted with a solution of 8% HCl. The acid solution, neutralized with NaHCO3, extracted with CH2Cl2, dried and evaporated, gave 0.6 g of 2-(1-imidazolyl)-3,4-dihydro-5,7-dibromo-1(2H)-naphthalenone;

출처