반응 #367324

반응 방정식

H2O

Sodium methoxide

7-Hydroxy-1-tetralone

N-(3-bromopropyl)phthalimide

→

desired product

7-(3-Phthalimidopropoxy)-tetralone

용매

dimethylformamide

반응 조건

후처리

1. 1
   온도the mixture is cooled in an ice bath
2. 2
   workup.STIRRINGstirring
3. 3
   workup.STIRRINGthe reaction mixture stirred overnight
4. 4
   workup.STIRRINGstirred for 1 hour
5. 5
   여과filtered
6. 6
   세척washed with H2O and air
7. 7
   기타dried
8. 8
   기타The resulting fluffy near-white solid (62.8 g) is crystallized from ethyl acetate

실험 절차

7-Hydroxy-1-tetralone (33.3 g) is dissolved in dimethylformamide (325 ml) and the mixture is cooled in an ice bath. Sodium methoxide (11.07 g) is added to the mixture. After the mixture is stirred for 3 min., N-(3-bromopropyl)phthalimide (54.96 g) is added to the mixture; stirring is continued and the reaction mixture stirred overnight. The resulting mixture is poured into H2O (650 ml), stirred for 1 hour, filtered, washed with H2O and air dried. The resulting fluffy near-white solid (62.8 g) is crystallized from ethyl acetate to give the desired product, a fluffy white solid (M.P. 149°-150° C.)

출처