반응 #367284

반응 방정식

sodium fluoride

ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-cyclopropylaminoacrylate

→

ethyl 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

수율 90.0%

용매

dimethylformamide

반응 조건

후처리

1. 1
   온도under reflux for 2 hours
2. 2
   workup.ADDITIONwhile hot, poured onto ice
3. 3
   여과The precipitate is filtered off with suction
4. 4
   세척thoroughly washed with water
5. 5
   건조dried over calcium chloride at 100° C. in vacuo

실험 절차

21.2 g of sodium fluoride are added to a solution of 107.8 g of ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-cyclopropylaminoacrylate in 400 ml of anhydrous dimethylformamide. The reaction mixture is then stirred under reflux for 2 hours and, while hot, poured onto ice. The precipitate is filtered off with suction, thoroughly washed with water and dried over calcium chloride at 100° C. in vacuo. 91.2 g of ethyl 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate of melting point 167°-168° C. are obtained.

출처