반응 #366475

반응 방정식

4-(aminomethyl)piperidine

K2CO3

4-chlorobenzyl chloride

→

4-(Aminomethyl)-1-(4-chlorobenzyl)piperidine

용매

CH3CN

반응 조건

후처리

1. 1
   온도cooled to 25° C.
2. 2
   농축concentrated
3. 3
   기타The residue was partitioned between CH2Cl2 (75 mL) and water (50 mL)
4. 4
   세척was washed with water (2×50 mL) and brine (1×50 mL)
5. 5
   건조The organic phase was dried (MgSO4)
6. 6
   농축concentrated

실험 절차

A solution of 4-(aminomethyl)piperidine (7.00 g, 61.3 mmol) in CH3CN (100 mL) was treated sequentially with K2CO3 (3.02 g) and 4-chlorobenzyl chloride (3.52 g, 21.8 mmol). The reaction mixture was heated to 60° C. for 16 h, cooled to 25° C. and concentrated. The residue was partitioned between CH2Cl2 (75 mL) and water (50 mL), and was washed with water (2×50 mL) and brine (1×50 mL). The organic phase was dried (MgSO4) and concentrated. Chromatography (SiO2, 4% H2O-iPrOH) afforded4-(aminomethyl)-1-(4-chlorobenzyl)piperidine (3.58 g, 69%).

출처