반응 #366106
ord-0b30e47a03f44611bad6c3265a653ad2
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타before quenching with aqueous NaHCO3 (30 mL)
- 2추출Extracted with EtOAc (3×50 mL)
- 3건조dried (MgSO4)
- 4농축concentrated to a residue which
- 5기타was purified by flash chromatography (EtOAc: Hexanes 9:1 to 1:1 )
실험 절차
To a suspension of 4-piperidinone monohydrate hydrochloride (2.00 g, 13.28 mmol) in CH2Cl2 (40 mL) and triethylamine (5.0 mL) was added 2,4-difluorobenzoyl chloride (2.84 g, 15.93 mmol). The resulting mixture was stirred at room temperature for 5 hours before quenching with aqueous NaHCO3 (30 mL). Extracted with EtOAc (3×50 mL), dried (MgSO4), and concentrated to a residue which was purified by flash chromatography (EtOAc: Hexanes 9:1 to 1:1 ) afford product as an oil (2.25 g, 71%).