반응 #365802

반응 방정식

1-(trans-4-aminocyclohexane-1-ylcarbonyl)-4-(6-chloronaphthalene-2-sulfonyl)piperazine hydrochloride

triethylamine

2-methylthioimidazoline

→

title compound

수율 52.4%

1-(6-Chloronaphthalene-2-sulfonyl)-4-[trans-4-(2-imidazolinylamino)cyclohexane-1-ylcarbonyl]piperazine hydrochloride

수율 52.4%

용매

ethanol

반응 조건

후처리

1. 1
   온도the mixture was heated for 48 hours
2. 2
   온도under reflux
3. 3
   농축The reaction solution was concentrated
4. 4
   기타the residue was purified with silica gel column chromatography (dichloromethane/methanol containing 10% ammonia=10/1)

실험 절차

To a solution of 1-(trans-4-aminocyclohexane-1-ylcarbonyl)-4-(6-chloronaphthalene-2-sulfonyl)piperazine hydrochloride (100 mg) and triethylamine (120 mg) in ethanol (10 ml) was added 2-methylthioimidazoline (116 mg), and the mixture was heated for 48 hours under reflux. The reaction solution was concentrated, and the residue was purified with silica gel column chromatography (dichloromethane/methanol containing 10% ammonia=10/1) and transformed into hydrochloride with 4 N hydrochloric acid in ethyl acetate to give a colorless solid of the title compound (30 mg).

출처