반응 #365757

반응 방정식

ethyl 2-(2-tert-butoxycarbonylamino-5-pyridyl)-4-methyl-5-thiazolecarboxylate

NaOH

HCl

→

title compound

수율 90.9%

2-(6-tert-Butoxycarbonylamino-3-pyridyl)-4-methyl-5-thiazolecarboxylic acid

수율 90.9%

용매

EtOH THF

반응 조건

실험 절차

A mixture of ethyl 2-(2-tert-butoxycarbonylamino-5-pyridyl)-4-methyl-5-thiazolecarboxylate (180 mg), 1N NaOH (2 ml) and EtOH-THF (2:1, 6 ml) was stirred at 70° C. for 1 hour, to which was added 1 N HCl (2 ml) to give the title compound (151 mg).

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