반응 #365644

반응 방정식

2-Hydroxyoctanoic acid

hydrogen chloride methanol

→

methyl 2-hydroxyoctanoate

반응 조건

후처리

1. 1
   기타the reaction mixture was evaporated under reduced pressure
2. 2
   기타The residue was partitioned between ethyl acetate and water
3. 3
   세척The organic layer was washed with aqueous NaHCO3 solution
4. 4
   건조dried over sodium sulfate
5. 5
   기타Evaporation of the solvent under reduced pressure

실험 절차

2-Hydroxyoctanoic acid (1.0 g) was stirred in 10% hydrogen chloride methanol solution (20 ml) at room temperature. After 1.5 hours, the reaction mixture was evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic layer was washed with aqueous NaHCO3 solution and dried over sodium sulfate. Evaporation of the solvent under reduced pressure gave methyl 2-hydroxyoctanoate (0.684 g) as a colorless oil.

출처