반응 #363363

반응 방정식

(E)-3-cyclohexyl-2-iodo-acrylic acid methyl ester

trimethylsilyl chloride

4-bromophenyl methyl sulfone

ammonium chloride

triphenylphosphine

1,2-dibromoethane

→

(E)-3-cyclohexyl-2-(4-methanesulfonyl-phenyl)-acrylic acid methyl ester

수율 99.8%

용매

tetrahydrofuran

tetrahydrofuran

tetrahydrofuran

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   온도to cool
2. 2
   온도heated again
3. 3
   workup.ADDITIONDuring the addition
4. 4
   기타rose to 50° C
5. 5
   workup.STIRRINGThe reaction mixture was then stirred at 40-45° C. for 1 h
6. 6
   workup.STIRRINGstirred overnight at 25° C
7. 7
   기타(˜2 h)
8. 8
   workup.STIRRINGwas stirred at 25° C. under argon for 10 min
9. 9
   온도The resulting brick red solution was heated at 50° C. for 24 h, at which time, thin layer chromatography analysis of the reaction mixture
10. 10
    온도The reaction mixture was cooled to 25° C.
11. 11
    추출the organic compound was extracted into ethyl acetate (3×100 mL)
12. 12
    세척The combined organic extracts were washed with a saturated aqueous sodium chloride solution (1×200 mL)
13. 13
    건조dried over anhydrous magnesium sulfate
14. 14
    여과filtered
15. 15
    농축concentrated in vacuo

실험 절차

A mixture of zinc dust (2.6 g, 40 mmol, Aldrich, −325 mesh) and dry tetrahydrofuran (3 mL) under argon was treated with 1,2-dibromoethane (0.37 g, 2 mmol). The zinc suspension was then heated with a heat gun to ebullition, allowed to cool, and heated again. This process was repeated three times to make sure the zinc dust was activated. The activated zinc dust suspension was then treated with trimethylsilyl chloride (217 mg, 2 mmol), and the suspension was stirred for 15 min at 25° C. The reaction mixture was then treated dropwise with a solution of (E)-3-cyclohexyl-2-iodo-acrylic acid methyl ester (5.88 g, 20 mmol) in dry tetrahydrofuran (5 mL) over 5 min. During the addition, the temperature rose to 50° C. The reaction mixture was then stirred at 40-45° C. for 1 h and then stirred overnight at 25° C. The reaction mixture was then diluted with dry tetrahydrofuran (10 mL), and the stirring was stopped to allow the excess zinc dust to settle down (˜2 h). In a separate reaction flask, bis(dibenzylideneacetone)palladium(0) (270 mg, 0.5 mmol) and triphenylphosphine (520 mg, 2 mmol) in dry tetrahydrofuran (25 mL) was stirred at 25° C. under argon for 10 min and then treated with 4-bromophenyl methyl sulfone (4.23 g, 18 mmol) and the freshly prepared zinc compound in tetrahydrofuran. The resulting brick red solution was heated at 50° C. for 24 h, at which time, thin layer chromatography analysis of the reaction mixture indicated the absence of starting material. The reaction mixture was cooled to 25° C. and then poured into a saturated aqueous ammonium chloride solution (150 mL), and the organic compound was extracted into ethyl acetate (3×100 mL). The combined organic extracts were washed with a saturated aqueous sodium chloride solution (1×200 mL), dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo. Flash chromatography (Merck Silica gel 60, 230-400 mesh, 3/2 hexanes/ethyl acetate) afforded (E)-3-cyclohexyl-2-(4-methanesulfonyl-phenyl)-acrylic acid methyl ester (5.79 g, 99%) as a low melting white solid: EI-HRMS m/e calcd for C17H22O4S (M+) 322.1238, found 322.1236.

출처