반응 #3632

반응 방정식

9,10-dihydro-10-(4-aminobenzoyl)-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

2-methylbenzoyl chloride

triethylamine

→

desired product

N-[4-(4H-Furo[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(9H)-ylcarbonyl)phenyl]-2-methyl benzamide

용매

methylene chloride

반응 조건

후처리

1. 1
   세척The reaction mixture is washed with water, 1N citric acid, NaHCO3, and brine
2. 2
   건조The reaction mixture is dried with Na2SO4
3. 3
   여과filtered
4. 4
   기타evaporated in vacuo
5. 5
   기타to give a solid which
6. 6
   기타is purified by flash chromatography on silica gel with ethyl acetate-hexane as solvent

실험 절차

To a stirred solution of 1.1 mmol of 2-methylbenzoyl chloride in 10 ml of methylene chloride is added 1.5 mmol of triethylamine. To the mixture is added 1.1 mmol of 9,10-dihydro-10-(4-aminobenzoyl)-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine and the mixture is stirred for 5 hours. The reaction mixture is washed with water, 1N citric acid, NaHCO3, and brine. The reaction mixture is dried with Na2SO4, filtered and evaporated in vacuo to give a solid which is purified by flash chromatography on silica gel with ethyl acetate-hexane as solvent to give the desired product as a solid.

출처