반응 #363176

반응 방정식

2,5-dimethylaniline

acetic anhydride

→

2′,5′-dimethylacetanilide

용매

dichloromethane

반응 조건

후처리

1. 1
   온도cooling
2. 2
   세척The reaction mixture was washed with 1N hydrochloric acid
3. 3
   건조a saturated aqueous sodium bicarbonate solution subsequently, and dried over anhydrous magnesium sulfate
4. 4
   기타Removal of the solvent in vacuo

실험 절차

To a stirred solution of 2,5-dimethylaniline (5.30 g) and 4-dimethylaminopyridine (6.41 g) in dichloromethane (90 ml) was added acetic anhydride (4.13 ml) under ice-cooling, and the mixture was stirred for 4 hours. The reaction mixture was washed with 1N hydrochloric acid and a saturated aqueous sodium bicarbonate solution subsequently, and dried over anhydrous magnesium sulfate. Removal of the solvent in vacuo gave 2′,5′-dimethylacetanilide (6.09 g).

출처