반응 #363059

반응 방정식

3,4-dihydroxybenzaldehyde

benzyl bromide

potassium carbonate

N,N-dimethylformamide

→

3,4-dibenzyloxybenzaldehyde

수율 182.2%

용매

water

반응 조건

후처리

1. 1
   추출was subjected to extraction with ethyl acetate (150 ml)
2. 2
   세척The organic layer was washed with a 5% aqueous solution of potassium hydrogencarbonate, which
3. 3
   세척was washed with water
4. 4
   건조dried over anhydrous sodium sulfate
5. 5
   workup.DISTILLATIONThe solvent was distilled off

실험 절차

A mixture of 3,4-dihydroxybenzaldehyde (5.0 g), benzyl bromide (14.8 g), potassium carbonate (13 g) and N,N-dimethylformamide (120 ml) was stirred for two hours at 60° C. To the reaction mixture was added cold water (200 ml), which was subjected to extraction with ethyl acetate (150 ml). The organic layer was washed with a 5% aqueous solution of potassium hydrogencarbonate, which was washed with water and dried over anhydrous sodium sulfate. The solvent was distilled off to leave 3,4-dibenzyloxybenzaldehyde (10.5 g) as colorless crystals. m.p.: 87-88° C.

출처