반응 #362840
ord-b0d1e0b5359340c1aa863386b79bc1a2
반응 방정식
sodium trimethylsilanolate
sodium trimethylsilanolate
ethyl N-(3-amino4-chloro-6-fluoro-2-methoxyphenyl)carbamate
DBU
DBU
sodium hydride
ethyl 3-amino4,4,4-trifluorocrotonate
→
title compound
3-(3-amino4-chloro-6-fluoro-2-methoxyphenyl)-6-trifluoromethyl-2,4-(1H,3H)-pyrimidinedione
반응물
시약
없음
용매
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타This compound was prepared
실험 절차
This compound was prepared using 4.0 grams (0.036 mole) of sodium trimethylsilanolate, 6.6 grams (0.036 mole) of ethyl 3-amino4,4,4-trifluorocrotonate, 8.5 grams (0.032 mole) of ethyl N-(3-amino4-chloro-6-fluoro-2-methoxyphenyl)carbamate, and 2.2 grams (0.014 mole) of DBU in 75 mL of DMF. This preparation differs from well-known literature preparations for pyrimidinedione rings in that sodium trimethylsilanolate and DBU were used rather than sodium hydride. The yield of title compound was 1.7 grams. The NMR spectrum was consistent with the proposed structure.