반응 #362830

반응 방정식

(S)-N-tert-butoxycarbonyl-4-O-(2-chloroethyl)tyrosine

→

(S)-4-O-(2-chloroethyl)tyrosine hydrochloride

수율 77.6%

용매

dioxane

반응 조건

후처리

1. 1
   기타are placed in a round-bottomed flask
2. 2
   농축the mixture is concentrated to dryness under reduced pressure
3. 3
   workup.STIRRINGthis solution is then stirred
4. 4
   여과filtered
5. 5
   세척The resulting solid is washed with 2 times 25 ml of ether
6. 6
   기타dried under reduced pressure in order

실험 절차

5 g of (S)-N-tert-butoxycarbonyl-4-O-(2-chloroethyl)tyrosine, dissolved in 50 ml of hydrochloric dioxane, are placed in a round-bottomed flask. After having been stirred for 28 h, the mixture is concentrated to dryness under reduced pressure. The resulting residue is taken up in 50 ml of ether and this solution is then stirred and filtered. The resulting solid is washed with 2 times 25 ml of ether and then dried under reduced pressure in order to yield 1.58 g of (S)-4-O-(2-chloroethyl)tyrosine hydrochloride in the form of a white solid which melts at 260° C.

출처