반응 #3624

반응 방정식

4,5-dihydro-5-(4-nitrobenzoyl)pyrrolo[1,2-a]quinoxaline

hydrazine

→

desired product

4,5-Dihydro-5(4-aminobenzoyl)pyrrolo[1,2-a]quinoxaline

용매

ethyl alcohol

반응 조건

후처리

1. 1
   온도heating
2. 2
   온도under reflux for 2 hours
3. 3
   여과The hot reaction mixture is filtered through diatomaceous earth
4. 4
   세척the filter cake washed with hot chloroform
5. 5
   농축the filtrate concentrated in vacuo
6. 6
   기타The residue is triturated with ethyl acetate
7. 7
   여과the mixture filtered

실험 절차

To a solution of 1 mmol of 4,5-dihydro-5-(4-nitrobenzoyl)pyrrolo[1,2-a]quinoxaline in 20 ml of ethyl alcohol is added 0.2 g of 10% Pd/C and 2.5 mmol of hydrazine followed by stirring and heating under reflux for 2 hours. The hot reaction mixture is filtered through diatomaceous earth and the filter cake washed with hot chloroform and the filtrate concentrated in vacuo. The residue is triturated with ethyl acetate and the mixture filtered to give the desired product as crystals, m.p. 225°-228° C.

출처