반응 #362092

반응 방정식

Triethylamine

4-phenoxyphenol

butyl isocyanate

→

tan solid

수율 99.1%

Butylcarbamic acid 4-phenoxyphenyl ester

수율 99.1%

용매

methylene chloride

반응 조건

후처리

1. 1
   workup.ADDITIONAfter the addition
2. 2
   추출The solution was extracted with 1 N HCl
3. 3
   건조dried (MgSO4)
4. 4
   기타the solvent removed under reduced pressure

실험 절차

Triethylamine (15 ml, 0.11 mol) was added dropwise under a nitrogen atmosphere to a solution of 4-phenoxyphenol (25.1 g, 0.14 mol) and butyl isocyanate (18 ml, 0.16 mol) in 400 ml of methylene chloride. After the addition, the solution was stirred overnight at room temperature. The solution was extracted with 1 N HCl, dried (MgSO4) and the solvent removed under reduced pressure to give 39.59 g of a tan solid. Recrystallization from diisopropyl ether gave the title compound as a white crystalline solid (21.01 g, 55%), mp 75°-77° C.

출처