반응 #361738

반응 방정식

5-(bromoacetyl)-2,3-dimethoxybenzonitrile

boron tribromide

sodium hydrogen carbonate

acetic acid

→

5-(bromoacetyl)-2,3- dihydroxybenzonitrile

용매

methylene chloride

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   세척The organic phase is washed with water
3. 3
   건조dried over sodium sulfate
4. 4
   기타evaporated

실험 절차

4.2 g of 5-(bromoacetyl)-2,3-dimethoxybenzonitrile dissolved in 150 ml of methylene chloride are treated with 8.9 ml of boron tribromide. The reaction mixture is stirred at 20° for 18 hours. It is subsequently poured into 220 ml of saturated sodium hydrogen carbonate solution and 100 g of ice, adjusted to pH 6 with glacial acetic acid and extracted with ethyl acetate. The organic phase is washed with water, dried over sodium sulfate and evaporated. There is obtained 5-(bromoacetyl)-2,3- dihydroxybenzonitrile as an amorphous solid.

출처