반응 #361685

반응 방정식

5'-cyano-3',4'-diacetoxyacetophenone

sodium hydroxide

hydrochloric acid

→

5'-cyano-3',4'-dihydroxyacetophenone

용매

methanol

sodium chloride

반응 조건

후처리

1. 1
   추출extracted twice with 30 ml of ethyl acetate each time
2. 2
   건조The combined ethyl acetate phases are dried over sodium sulfate
3. 3
   기타evaporated
4. 4
   기타The residue is recrystallized from toluene/acetonitrile

실험 절차

0.33 g of 5'-cyano-3',4'-diacetoxyacetophenone dissolved in 3.3 ml of methanol is treated with 2.7 ml of 1.0N sodium hydroxide solution and the reaction mixture is stirred at 23° for 45 minutes. The mixture is subsequently acidified with 2N hydrochloric acid, diluted with 5 ml of saturated sodium chloride solution and extracted twice with 30 ml of ethyl acetate each time. The combined ethyl acetate phases are dried over sodium sulfate and evaporated. The residue is recrystallized from toluene/acetonitrile. There is obtained 5'-cyano-3',4'-dihydroxyacetophenone as brownish crystals which decompose above 215°.

출처