반응 #361433

반응 방정식

toluene

SOCl2

furanoic acid

1,2-dimethoxyethane

ammonia

→

white crystals

2-(4-methylphenyl)furan-3-carboxamide

반응 조건

후처리

1. 1
   온도The mixture is refluxed for 3 h
2. 2
   workup.DISTILLATIONthe excess SOCl2 and the toluene are then distilled
3. 3
   기타to give an oil, which
4. 4
   여과The precipitate is filtered off
5. 5
   세척washed with water

실험 절차

20 ml of SOCl2 are added to a solution of the 13.4 g of furanoic acid prepared above in 70 ml of toluene. The mixture is refluxed for 3 h and the excess SOCl2 and the toluene are then distilled to give an oil, which is reacted at 5° C. with a solution of 100 ml of 1,2-dimethoxyethane saturated with ammonia. The precipitate is filtered off and washed with water and then with isopropyl alcohol to give 7 g of white crystals of amide.

출처