반응 #361

반응 방정식

CN1Cc2ccc(Cl)nc2OC(C

COc1cc(N)ccc1-n1cnc(

→

COc1cc(Nc2ccc3c(n2)O

용매

COCCOC

반응 조건

실험 절차

3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (0.031 g, 0.15 mmol), 8-chloro-2-cyclopropyl-4-methyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (0.036 g, 0.15 mmol), Palladium acetate (3.39 mg, 0.02 mmol), 2-(Dicyclohexylphosphino)biphenyl (5.29 mg, 0.02 mmol) and Cesium carbonate (0.049 g, 0.15 mmol) were added in a microwave vial. The mixture was capped and flushed with argon. 1,2-dimethoxyethane (2 mL) was added and the mixture was run in a microwave for 60 minutes at 100°C. Extremely little product was formed according to LCMS and all oxazepinestartingmaterial was consumed. Did not isolate, discarded.

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