반응 #360943

반응 방정식

2-phenylcyclohexanone

bromine

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product

수율 43.9%

2-Bromo-6-phenylcyclohexanone

수율 43.9%

용매

carbon tetrachloride

carbon tetrachloride

반응 조건

후처리

1. 1
   온도to maintain the reaction temperature below 5° C
2. 2
   농축The mixture was concentrated in vacuo to a brown solid
3. 3
   기타the solid triturated with methanol
4. 4
   여과The resulting white solid was collected by filtration

실험 절차

A solution of 15 g (86 mmole) of 2-phenylcyclohexanone in 60 mL of carbon tetrachloride at -5° C. was treated via rapid dropwise addition with a solution of 14.4 g (90 mmole) of bromine in 70 mL of carbon tetrachloride so as to maintain the reaction temperature below 5° C. The color disappeared rapidly. The mixture was concentrated in vacuo to a brown solid and the solid triturated with methanol. The resulting white solid was collected by filtration to provide 9.55 g of product. After cooling the mother liquor at -25° C., an additional 5.2 g of solid was obtained, for a total yield of 68%, a portion of which was carried on directly in Step B below.

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