반응 #3600

반응 방정식

3-chloro-10,11-dihydro-10-(4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

triethylamine

2-methylbenzoylchloride

→

N-[4-(3-Chloro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)ylcarbonyl)phenyl]-2-methylbenzamide

용매

dichloromethane

반응 조건

후처리

1. 1
   세척The mixture is washed with water, and 1M NaHCO3 and dried(Na2 SO4)
2. 2
   기타The solvent is removed in vacuo
3. 3
   기타to give a solid which
4. 4
   기타is recrystallized from dichloromethane-hexane
5. 5
   기타to give crystals, 185°-187° C.

실험 절차

A mixture of 1 mmol of 3-chloro-10,11-dihydro-10-(4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine, 2 mmol of triethylamine, and 1.1 mmol of 2-methylbenzoylchloride in 8 ml of dichloromethane is stirred at room temperature overnight. The mixture is washed with water, and 1M NaHCO3 and dried(Na2 SO4). The solvent is removed in vacuo to give a solid which is recrystallized from dichloromethane-hexane to give crystals, 185°-187° C.

출처