반응 #359739

반응 방정식

bromomethyl cyclopropane

4-piperidone hydrate hydrochloride

sodium carbonate

→

title compound

수율 55.3%

1-Cyclopropylmethyl-piperidin-4-one

수율 55.3%

용매

acetonitrile

반응 조건

후처리

1. 1
   여과The resulting suspension was filtered
2. 2
   세척the solid was washed with acetonitrile
3. 3
   농축The filtrate was concentrated in vacuo
4. 4
   기타purified by column chromatography on silica eluting with DCM/2N NH3 in methanol 97:3

실험 절차

To a suspension of bromomethyl cyclopropane (4 mmol) and 4-piperidone hydrate hydrochloride (4 mmol) in acetonitrile (30 mL) was added sodium carbonate (11 mmol). The reaction mixture was stirred 16 h at 85° C. The resulting suspension was filtered and the solid was washed with acetonitrile. The filtrate was concentrated in vacuo and purified by column chromatography on silica eluting with DCM/2N NH3 in methanol 97:3 to yield 339 mg of the title compound as yellow oil. MS (m/e): 154.2 (MH+, 100%).

출처