반응 #359561

ord-2e3ac3ca294e44e6b67731b3c3d90cb8

반응 방정식

Cc1c(C)c2c(c(C)c1N)C(c1ccc(C(C)C)cc1)C(C)(C)O2
3-(4-isopropylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine
O=C(Cl)c1ccc2c(c1)OCO2
1,3-benzodioxol-5-carbonyl chloride
→
Cc1c(C)c2c(c(C)c1NC(=O)c1ccc3c(c1)OCO3)C(c1ccc(C(C)C)cc1)C(C)(C)O2
title compound
수율 67.0%
Cc1c(C)c2c(c(C)c1NC(=O)c1ccc3c(c1)OCO3)C(c1ccc(C(C)C)cc1)C(C)(C)O2
N-[3-(4-Isopropylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl]-1,3-benzodioxol-5-carboxamide
수율 67.0%

반응물

Cc1c(C)c2c(c(C)c1N)C(c1ccc(C(C)C)cc1)C(C)(C)O2
3-(4-isopropylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine
O=C(Cl)c1ccc2c(c1)OCO2
1,3-benzodioxol-5-carbonyl chloride

시약

없음

용매

CCCCCC.CCOCC
Ethyl ether hexane

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

By using 3-(4-isopropylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine and 1,3-benzodioxol-5-carbonyl chloride, the title compound was synthesized according to Example 1b. Yield: 67%. Melting point: 165-167° C. (Ethyl ether-hexane)

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07456162B2uspto-grants-2008_11