반응 #359248

반응 방정식

3-(benzyloxycarbonyl)amino-N-({(3R)-1-(tert-butoxycarbonyl)-3-piperidyl}methyl)propanamide

→

title compound

수율 89.9%

3-(benzyloxycarbonyl)amino-N-{((3S)-3-piperidyl)methyl}propanamide

수율 89.9%

용매

chloroform

trifluoroacetic acid

반응 조건

후처리

1. 1
   workup.WAITfollowed by an hour
2. 2
   기타The reaction liquid
3. 3
   workup.DISTILLATIONwas distilled off under reduced pressure
4. 4
   추출Extracting the product with chloroform
5. 5
   건조the product was dried over anhydrous sodium sulfate
6. 6
   workup.DISTILLATIONUpon distilling the solvent off under reduced pressure

실험 절차

To a solution of 1.84 g of 3-(benzyloxycarbonyl)amino-N-({(3R)-1-(tert-butoxycarbonyl)-3-piperidyl}methyl)propanamide in 2 ml of chloroform, 2 ml of trifluoroacetic acid was added at room temperature, followed by an hour's stirring at the same temperature. The reaction liquid was distilled off under reduced pressure, and the residue was rendered basic with 4N aqueous sodium hydroxide solution. Extracting the product with chloroform, the product was dried over anhydrous sodium sulfate. Upon distilling the solvent off under reduced pressure, 1.26 g of the title compound was obtained.

출처