반응 #358529

반응 방정식

3-tert-butoxycarbonylmethylene-cyclobutanecarboxylic acid

hydrogen

→

product

수율 99.1%

cis-3-tert-Butoxycarbonylmethyl-cyclobutanecarboxylic acid

수율 99.1%

용매

ethanol

ethanol

반응 조건

후처리

1. 1
   여과filtered
2. 2
   workup.ADDITIONdiluted with 20 mL of toluene
3. 3
   농축concentrated under reduced pressure
4. 4
   기타Drying under vacuum overnight

실험 절차

A mixture of 2 g of 3-tert-butoxycarbonylmethylene-cyclobutanecarboxylic acid, 150 mL of ethanol, 0.5 g of 5% platinum on carbon, and 200 mL of ethanol was stirred under 1 atm of hydrogen for 48 h overnight, filtered, diluted with 20 mL of toluene and concentrated under reduced pressure. Drying under vacuum overnight gave 2 g of product, which was predominantly as a colorless oil: 1H NMR (400 MHz, CDCl3) 10.2 (br s, 1H), 3.0 (m, 1H), 2.3 (m, 1H), 2.38 (m, 4H), 2.0 (dd, 2H), 1.4 (s, 9).

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