반응 #357873

반응 방정식

2,6-dichloro-phenyl-acetonitrile

HNO3

→

product

수율 82.4%

2,6-dichloro-3-nitrophenyl-acetonitrile

수율 82.4%

용매

dichloromethane

H2SO4

H2SO4

반응 조건

후처리

1. 1
   workup.WAITwarned to room temperature for half hour
2. 2
   농축concentrated
3. 3
   기타to remove organic solvent
4. 4
   workup.ADDITIONThe solution is poured into a beaker
5. 5
   workup.ADDITIONcontaining ice-water (400 mL)
6. 6
   기타to give a crystalline precipitate, which
7. 7
   여과is collected by vacuum filtration
8. 8
   세척washed with water

실험 절차

To a solution of 2,6-dichloro-phenyl-acetonitrile (15.0 g, 80.62 mmol) in the dichloromethane (50 mL) and H2SO4 (40 mL) is added (slowly) a mixture of H2SO4 (14 mL) and HNO3 (5.5 mL) at 0° C. The reaction mixture is stirred at 0° C. for 20 minutes, warned to room temperature for half hour, and then concentrated to remove organic solvent. The solution is poured into a beaker containing ice-water (400 mL) to give a crystalline precipitate, which is collected by vacuum filtration and washed with water to afford the product (20.44 g, 82.4%).

출처