반응 #357281

반응 방정식

piperidine

ethyl chloroformate

potassium hydroxide

1′-benzyl-5-chloro-3H-spiro[1-benzofuran-2,3′-pyrrolidine]

→

titled compound

수율 61.9%

5-Chloro-3H-spiro[1-benzofuran-2,3′-pyrrolidine]

수율 61.9%

용매

toluene

water

dichloromethane

ammonium hydroxide

NH4OH

methanol

ethanol

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실험 절차

The experimental procedure is the same as described above for the corresponding piperidine derivative using 1′-benzyl-5-chloro-3H-spiro[1-benzofuran-2,3′-pyrrolidine] (555 mg, 1.85 mmol), ethyl chloroformate (261 mg, 2.4 mmol), toluene (5 mL), potassium hydroxide (KOH) (3.0 g), water (3 mL) and ethanol (6 mL) to give the titled compound (240 mg) after silica gel flash chromatography (0-2% methanol in dichloromethane, 0.2% ammonium hydroxide, NH4OH).

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