반응 #357106

반응 방정식

1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine

1-(2-cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)-piperazine

→

4-[4-(2-cyclohexylethyl)piperazin-1-yl]-2,5-difluorophenol

수율 36.3%

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후처리

1. 1
   기타The resulting crude product was purified on TLC (developer, chloroform: methanol=13:1)

실험 절차

Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-(2-cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)-piperazine (250 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=13:1) to provide 4-[4-(2-cyclohexylethyl)piperazin-1-yl]-2,5-difluorophenol (87 mg).

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