반응 #357105

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2-cyclohexylethyl methylsulfonate

1-(4-methoxyphenyl)piperazine dihydrochloride

(2-bromoethyl)-benzene

1-(2,5-difluoro-4-methoxyphenyl)-piperazine

→

1-(2-cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine

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실험 절차

Production Example 1 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and (2-bromoethyl)-benzene were replaced with 1-(2,5-difluoro-4-methoxyphenyl)-piperazine (342 mg) and 2-cyclohexylethyl methylsulfonate (309 mg), respectively, to provide crude 1-(2-cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine (476 mg).

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