반응 #357073

반응 방정식

1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine

1-(2-cyclohexylethyl)-4-(3-fluoro-4-methoxyphenyl)piperazine

→

4-(2-cyclohexylethyl-piperazin-1-yl]-2-fluorophenol

반응 조건

후처리

1. 1
   기타the resulting crude product was purified on TLC (developer, chloroform: methanol=18:1)

실험 절차

Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-(2-cyclohexylethyl)-4-(3-fluoro-4-methoxyphenyl)piperazine (218 mg) and the resulting crude product was purified on TLC (developer, chloroform: methanol=18:1) to provide 4-[4-(2-cyclohexylethyl-piperazin-1-yl]-2-fluorophenol (77 mg).

출처