반응 #357072

반응 방정식

2-cyclohexylethyl bromide

1-(4-methoxyphenyl)piperazine dihydrochloride

(2-bromoethyl)-benzene

1-(3-fluoro-4-methoxyphenyl)piperazine

→

1-(2-cyclohexylethyl)-4-(3-fluoro-4-methoxyphenyl)piperazine

반응 조건

후처리

1. 1
   기타Thus obtained crude product
2. 2
   기타was purified on silica gel column chromatography (eluent, chloroform: methanol=30:1)

실험 절차

Production Example 1 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and (2-bromoethyl)-benzene were replaced with 1-(3-fluoro-4-methoxyphenyl)piperazine (456 mg) and 2-cyclohexylethyl bromide (377 μL), respectively. Thus obtained crude product was purified on silica gel column chromatography (eluent, chloroform: methanol=30:1) to provide 1-(2-cyclohexylethyl)-4-(3-fluoro-4-methoxyphenyl)piperazine (229 mg).

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