반응 #3570

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6-(3-methoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

6-(3-Methoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

tert-butyl isocyanate

→

title compound

1-[2-Amino-6-(3-methoxy-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl-urea

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후처리

1. 1
   기타The product was purified by medium pressure liquid chromatography
2. 2
   세척eluting with a gradient of CHCl3 :EtOAc (2:1) to CHCl3 :EtOAc (1:1) to EtOAc

실험 절차

The title compound was prepared from 0.50 g of 6-(3-methoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 102 and 0.23 mL tert-butyl isocyanate according to Example 2. The product was purified by medium pressure liquid chromatography eluting with a gradient of CHCl3 :EtOAc (2:1) to CHCl3 :EtOAc (1:1) to EtOAc; mp 275°-280° C.; MS(CI).

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