반응 #356836

반응 방정식

benzyl(2-aminoethyl)carbamate hydrochloride

HATU

N,N-diisopropylethylamine

N-(tert-butoxycarbonyl)-L-serine

DMF

→

Benzyl(2-{[N-(tert-butoxycarbonyl)-L-seryl]amino}ethyl)carbamate

반응 조건

후처리

1. 1
   workup.STIRRINGThe reaction mixture is stirred at RT for 15 h
2. 2
   기타The solvent is then evaporated
3. 3
   세척The organic phase is washed with water
4. 4
   건조dried over magnesium sulfate
5. 5
   농축concentrated
6. 6
   기타The crude product is purified by preparative HPLC

실험 절차

627.4 mg (1.650 mmol) of HATU and 387.7 mg (3.0 mmol) of N,N-diisopropylethylamine are added to a solution of 307.8 mg (1.50 mmol) of N-(tert-butoxycarbonyl)-L-serine in 25 ml of anhydrous DMF. After stirring at RT for 15 min, 380.6 mg (1.650 mmol) of benzyl(2-aminoethyl)carbamate hydrochloride are added. The reaction mixture is stirred at RT for 15 h. The solvent is then evaporated and the residue is taken up in dichloromethane. The organic phase is washed with water, dried over magnesium sulfate and concentrated. The crude product is purified by preparative HPLC.

출처