반응 #3568

반응 방정식

6-(2-methoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

6-(2-Methoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

tert-butyl isocyanate

→

title compound

1-[2-Amino-6-(2-methoxy-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl-urea

반응 조건

후처리

1. 1
   기타The product was purified by medium pressure liquid chromatography
2. 2
   세척eluting with 1:1CHCl3

실험 절차

The title compound was prepared from 0.203 g of 6-(2-methoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 100 and 0.093 mL of tert-butyl isocyanate according to Example 2. The product was purified by medium pressure liquid chromatography eluting with 1:1CHCl3 :EtOAc; mp 300°-301° C.; CIMS (1% ammonia in methane): m/z (relative intensity) 367 (MH+ +1, 67), 368 (MH+ +2, 14), 236 (100).

출처