반응 #356619

반응 방정식

diethyl ether

N-(3,5-Dimethoxy-phenyl)-4-methyl-benzenesulfonamide

1-bromoheptane

potassium carbonate

Diethyl ether

→

title compound

수율 96.4%

N-(3,5-Dimethoxy-phenyl)-N-heptyl-4-methyl-benzenesulfonamide

수율 96.4%

용매

DMF

반응 조건

후처리

1. 1
   온도cooled to room temperature
2. 2
   추출to extract the product
3. 3
   기타The ethereal solution was separated
4. 4
   세척washed with water, brine
5. 5
   건조dried with Na2SO4
6. 6
   기타Removal of solvent
7. 7
   기타drying reagent
8. 8
   기타provided 19.50 g of light yellow liquid, which

실험 절차

A mixture of N-(3,5-Dimethoxy-phenyl)-4-methyl-benzenesulfonamide (15.0 g, 48.9 mmol), 1-bromoheptane (9.63 g, 53.8 mmol) and potassium carbonate (17.1 g, 124.2 mmol) in anhydrous DMF (100 mL) was stirred and heated at 120 ° C. for 4 h, and then cooled to room temperature and poured into ice-cold water (400 mL). Diethyl ether (400 mL) was added to extract the product. The ethereal solution was separated and washed with water, brine and dried with Na2SO4. Removal of solvent and drying reagent provided 19.50 g of light yellow liquid, which was treated with small amount of diethyl ether to give 19.10 g (96.4%) of the title compound as a white solid upon cooling.

출처