반응 #3565

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6-(2,4,6-trimethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

6-(2,4,6-Trimethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

tert-butyl isocyanate

→

title compound

1-[2-Amino-6-(2,4,6-trimethyl-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl-urea

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후처리

1. 1
   기타The product was purified by medium pressure liquid chromatography
2. 2
   세척eluting with 1:1 CHCl3

실험 절차

The title compound was prepared from 0.25 g of 6-(2,4,6-trimethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 96 and 0.109 mL of tert-butyl isocyanate according to Example 2. The product was purified by medium pressure liquid chromatography eluting with 1:1 CHCl3 :EtOAc; mp 281°-297° C.; CIMS (1% ammonia in methane): m/z (relative intensity) 379 (MH+ +1, 100), 380 (MH+ +2, 23).

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