반응 #3563

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6-(3,5-dimethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

6-(3,5-Dimethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

tert-butyl isocyanate

→

title compound

1-[2-Amino-6-(3,5-dimethyl-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl-urea

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후처리

1. 1
   기타The product is purified by MPLC
2. 2
   세척eluting with 1:1 CHCl3

실험 절차

The title compound was prepared from 0.3 g of 6-(3,5-dimethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 94 and 0.14 mL of tert-butyl isocyanate according to Example 2. The product is purified by MPLC eluting with 1:1 CHCl3 :EtOAc; mp 180°-182° C., CIMS (1% ammonia in methane): m/z (relative intensity) 365 (MH+ +1, 16), 366 (MH+ +2, 3), 84 (100).

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