반응 #355783

반응 방정식

4-(methylthio)benzoic acid

N-[2-(dimethylamino)ethyl]-N′-ethylcarbodiimide hydrochloride

morpholine

→

title compound

4-{[4-(methylthio)phenyl]carbonyl}morpholine

용매

THF

반응 조건

후처리

1. 1
   농축the reaction was concentrated in vacuo
2. 2
   기타the residue partitioned between ethyl acetate (100 mL) and 2M hydrochloric acid (150 mL)
3. 3
   기타The organic phase was separated
4. 4
   세척washed with 1M aqueous sodium carbonate solution
5. 5
   건조dried over sodium sulfate
6. 6
   여과filtered
7. 7
   농축concentrated in vacuo

실험 절차

To a stirred solution of 4-(methylthio)benzoic acid (6.76 g, 40.2 mmol) and N-[2-(dimethylamino)ethyl]-N′-ethylcarbodiimide hydrochloride (9.24 g, 48.2 mmol) in THF (100 mL) was added morpholine (4.2 mL, 48.2 mmol). After stirring for 2 hours, the reaction was concentrated in vacuo and the residue partitioned between ethyl acetate (100 mL) and 2M hydrochloric acid (150 mL). The organic phase was separated, washed with 1M aqueous sodium carbonate solution, dried over sodium sulfate, filtered and concentrated in vacuo to give the title compound LC retention time 3.52 mins MS m/z 238 (MH+).

출처