반응 #355740

반응 방정식

2-fluoro-5-nitrotoluene

N-methylpyrrolidinone

2-aminoethoxyethanol

K2CO3

→

2-[2-(4-nitro-2-methylphenylamino)ethoxy]ethanol

용매

water

반응 조건

후처리

1. 1
   온도after cooling to room temperature
2. 2
   추출The resulting medium was extracted with ethyl acetate
3. 3
   농축the organic phase was then concentrated under vacuum

실험 절차

2 g of 2-fluoro-5-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.63 g of 2-aminoethoxyethanol and 2.14 g of K2CO3. The reaction medium was heated at 60° C. for 12 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The resulting medium was extracted with ethyl acetate and the organic phase was then concentrated under vacuum. 2.2 g of 2-[2-(4-nitro-2-methylphenylamino)ethoxy]ethanol (13) were obtained.

출처