반응 #355635

반응 방정식

1-methyl-2-nicotinoyl-hydrazine

4-cyanopyridine

sodium

→

1-methyl-3-(3-pyridyl)-5-(4-pyridyl)-1,2,4-triazole

용매

methanol

methanol

반응 조건

후처리

1. 1
   온도The reaction mixture is heated 5 hours
2. 2
   온도at reflux
3. 3
   농축is concentrated to an oil which
4. 4
   기타After chromatography on silica gel and recrystallization from acetonitrile 0.8 g

실험 절차

To 4-cyanopyridine (2g.) in methanol (30 ml.) is added sodium (0.1 g.). The solution is allowed to stand 0.5 hours at ambient temperature and is then added to a solution of 1-methyl-2-nicotinoyl-hydrazine (3 g.) in methanol (30 ml.). The reaction mixture is heated 5 hours at reflux and is concentrated to an oil which solidifies. After chromatography on silica gel and recrystallization from acetonitrile 0.8 g. of 1-methyl-3-(3-pyridyl)-5-(4-pyridyl)-1,2,4-triazole melting 132°-133° C is obtained.

출처