반응 #3555

반응 방정식

6-(2,6-difluoro-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

6-(2,6-Difluoro-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

tert-butyl isocyanate

ammonia

→

title compound

1-[2-Amino-6-(2,6-difluoro-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl-urea

용매

methane

반응 조건

후처리

1. 1
   기타The product was purified by MPLC
2. 2
   세척eluting with a gradient of CHCl3 :EtOAc (1:1) to EtOAc
3. 3
   기타to afford the pure product

실험 절차

The title compound was prepared from 0.25 g of 6-(2,6-difluoro-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 63 and 0.112 mL of tert-butyl isocyanate according to Example 2. The product was purified by MPLC eluting with a gradient of CHCl3 :EtOAc (1:1) to EtOAc to afford the pure product; mp >300° C., CIMS (1% ammonia in methane): m/z (relative intensity) 373 (MH+ +1, 60), 374 (MH+ +2, 10), 274 (100).

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