반응 #354810

ord-389877487dba43be8a21289e95b57243

반응 방정식

C[C@]12CC[C@@H](O)C[C@H]1CC[C@H]1[C@@H]3CC[C@H](C(=O)OCCN4CCOCC4)[C@@]3(C)CC(=O)[C@@H]12
3α-hydroxy-17β-(2'-morpholinoethoxycarbonyl)-5β-androstan-11-one
O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
→
C[C@]12CC[C@@H](O)C[C@H]1CC[C@H]1[C@@H]3CC[C@H](C(=O)OCCN4CCOCC4)[C@@]3(C)CC(=O)[C@@H]12.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-]
title compound
수율 10.0%
C[C@]12CC[C@@H](O)C[C@H]1CC[C@H]1[C@@H]3CC[C@H](C(=O)OCCN4CCOCC4)[C@@]3(C)CC(=O)[C@@H]12.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-]
3α-Hydroxy-17β-(2'-morpholinoethoxycarbonyl)-5β-androstan-11-one citrate
수율 10.0%

반응물

C[C@]12CC[C@@H](O)C[C@H]1CC[C@H]1[C@@H]3CC[C@H](C(=O)OCCN4CCOCC4)[C@@]3(C)CC(=O)[C@@H]12
3α-hydroxy-17β-(2'-morpholinoethoxycarbonyl)-5β-androstan-11-one
O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid

시약

없음

용매

CCO
ethanol

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타the resulting mixture was evaporated to dryness
  2. 2
    workup.ADDITIONThe residue was treated with water (1.1 ml)

실험 절차

A solution of 3α-hydroxy-17β-(2'-morpholinoethoxycarbonyl)-5β-androstan-11-one (112 mg., 0.25 mmole) in ethanol (2 ml.) was treated with 0.01 N aqueous citric acid (2.5 ml; 0.25 mmole) and the resulting mixture was evaporated to dryness. The residue was treated with water (1.1 ml) to give an aqueous solution of the title compound (10% with respect to free steroidal base).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US03943124uspto-grants-1976_03