반응 #354103

반응 방정식

2-methoxy-5-nitrobenzyl bromide

1,4,7,10-tetraazacyclododecane

→

N-(2-methoxy-5-nitrobenzyl)-1,4,7,10-tetraazacyclododecane

수율 79.0%

용매

chloroform

chloroform

반응 조건

후처리

1. 1
   여과was filtered
2. 2
   농축the filtrate concentrated (in vacuo)
3. 3
   기타to give a residue which
4. 4
   기타was chromatographed (silica, Solvent System 3)
5. 5
   기타The monoalkylated product was isolated in 79 percent yield (MP=154°-156° C.)

실험 절차

To a stirred chloroform solution (20 ml) containing 2.9 g of 1,4,7,10-tetraazacyclododecane (16.8 mmole) was added a chloroform solution (20 ml) containing 2.1 g of 2-methoxy-5-nitrobenzyl bromide (8.5 mmole) in one portion. After stirring at room temperature for three hours the reaction mixture was filtered and the filtrate concentrated (in vacuo) to give a residue which was chromatographed (silica, Solvent System 3). The monoalkylated product was isolated in 79 percent yield (MP=154°-156° C.), and characterized by:

출처