반응 #353898

반응 방정식

2-nitroimidazole

potassium carbonate

(S)-(+)-epichlorohydrin

→

(S)-(+)-α-(Chloromethyl)-2-nitro-1H-imidazole-1-ethanol

반응 조건

후처리

1. 1
   온도is refluxed for 10 minutes
2. 2
   여과then filtered while hot
3. 3
   농축The filtrate is concentrated
4. 4
   온도cooled
5. 5
   기타to give a solid
6. 6
   기타Crystallization from ethanol and further processing
7. 7
   기타gives the product

실험 절차

Alternatively, a mixture of 2-nitroimidazole, anhydrous potassium carbonate, and (S)-(+)-epichlorohydrin is refluxed for 10 minutes then filtered while hot. The filtrate is concentrated and cooled to give a solid. Crystallization from ethanol and further processing gives the product.

출처