반응 #352409

반응 방정식

2-indanol

pyridine

PBr3

→

2-bromoindane

수율 45.0%

용매

chloroform

반응 조건

후처리

1. 1
   추출extracted by addition of 450 mL of chloroform and 500 g of ice
2. 2
   세척The organic layer was washed twice with water
3. 3
   건조dried over Na2SO4
4. 4
   기타The solvent was evaporated in vacuo
5. 5
   기타leaving a brown semi-solid
6. 6
   workup.DISTILLATIONThe product was distilled rapidly in vacuo

실험 절차

To 2-indanol (Aldrich) (105 g, 0.78 mol) in pyridine (16 mL, 0.2 mol) and 340 mL of chloroform at -15 C. was added PBr3 (84 mL, 0.89 mol) over 45 min. The reaction mixture was stirred overnight at room temperature and extracted by addition of 450 mL of chloroform and 500 g of ice. The organic layer was washed twice with water, and dried over Na2SO4. The solvent was evaporated in vacuo, leaving a brown semi-solid. The product was distilled rapidly in vacuo and then fractionated to give 69 g (45%) 2-bromoindane, bp 90-93 /3 mmHg; nd23 =1.5837.

출처