반응 #352094
ord-203cc9548934400e91597e87c78c9044
반응 방정식
sodium boranate
4-benzyloxy-3-(3-methoxypropyloxy)-benzaldehyde
→
title compound
4-Benzyloxy-3-(3-methoxypropyloxy)-benzyl alcohol
반응 조건
온도
0°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1농축is then concentrated by evaporation
- 2기타The residue is partitioned between diethyl ether and water
- 3건조The combined organic phases are dried over sodium sulfate
- 4농축concentrated by evaporation
- 5기타the residue is purified by FC (100 g of silica gel, dichloromethane/diethyl ether=1:1)
실험 절차
A solution of 31 g of 4-benzyloxy-3-(3-methoxypropyloxy)-benzaldehyde in 530 ml of ethanol/water=8:2 is added dropwise to a suspension, stirred at 0° C., of 11.74 g of sodium boranate in 530 ml of a mixture of ethanol/water=8:2. The reaction mixture is stirred for one hour at 0° C. and is then concentrated by evaporation. The residue is partitioned between diethyl ether and water. The combined organic phases are dried over sodium sulfate and concentrated by evaporation, and the residue is purified by FC (100 g of silica gel, dichloromethane/diethyl ether=1:1), yielding the title compound: Rf (dichloromethane/diethyl ether=1:1)=0.43.