반응 #351941

반응 방정식

2-phenylimidazole

→

2-cyclohexylimidazole

용매

hydrochloric acid

반응 조건

후처리

1. 1
   여과then filtered through celite
2. 2
   추출extracted with 2×100 mL ethyl acetate
3. 3
   추출The combined extract
4. 4
   세척was washed with 200 mL of brine
5. 5
   건조dried over anhydrous sodium sulfate
6. 6
   기타Evaporation of the solvent

실험 절차

To a solution of 6.8 g of 2-phenylimidazole in 200 mL 3N hydrochloric acid was added 5% Rhodium on Carbon, Degussa type G10 NB/W. The mixture was hydrogenated at 100 psi for 24 hours then filtered through celite. The solution was neutralized with 25% sodium hydroxide and extracted with 2×100 mL ethyl acetate. The combined extract was washed with 200 mL of brine and dried over anhydrous sodium sulfate. Evaporation of the solvent gave 2-cyclohexylimidazole as a fluffy, white solid which was used in the next step without further purification or characterization.

출처