반응 #351083

반응 방정식

water

9H-indeno[1,2-b]pyrazine-2,3,9(1H,4H)-trione

water

sodium borohydride

hydrochloric acid

→

title compound

수율 91.0%

9-Hydroxy-9H-indeno[1,2-b]pyrazine-2,3(1H,4H) -dione

수율 91.0%

용매

ethanol

반응 조건

후처리

1. 1
   여과the precipitate was filtered off
2. 2
   세척washed with water
3. 3
   기타dried

실험 절차

To a stirred suspension of 9H-indeno[1,2-b]pyrazine-2,3,9(1H,4H)-trione.-1H2O (5.0 g, 21.5 mmol) in 200 ml of ethanol and 30 ml of water was added sodium borohydride (1.76 g, 46.5 mmol) in four portions over 2 hours, then 200 ml of water was added and the mixture was stirred for 18 hours at room temperature. The reaction mixture was acidified with hydrochloric acid (70 ml, 1N) to pH 1.5 and the precipitate was filtered off, washed with water and dried to give 4.59 g (91%) of the title compound. M.p.>300° C. 1H-NMR (DMSO-d6, δ): 5.1 (d, 1H), 5.72 (d, 1H), 7.15 (t, 1H), 7.28 (t, 1H), 7.41 (d, 1H), 7.48 (d, 1H), 12.0 (s, 1H), 12.25 (s, 1H).

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