반응 #350762

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4,5-diethoxycarbonyl-2-(3,4-diethoxyphenyl)thiazole

hydrazine hydrate

→

2-(3,4-diethoxyphenyl)-5,6-dihydrothiazolo[4,5-d]pyridazine-4,7-dione

용매

ethanol

반응 조건

후처리

1. 1
   기타The mixture was sealed in a tube
2. 2
   온도After cooling
3. 3
   여과the resulting crystals were collected by filtration
4. 4
   세척washed with ethanol
5. 5
   기타dried
6. 6
   기타recrystallized from dimethylformamide

실험 절차

In 4 ml of ethanol was suspended 1 g of 4,5-diethoxycarbonyl-2-(3,4-diethoxyphenyl)thiazole. Thereto was added 2 ml of hydrazine hydrate. The mixture was sealed in a tube and heated at 130° C. for 48 hours. After cooling, the resulting crystals were collected by filtration, washed with ethanol, dried and recrystallized from dimethylformamide to obtain 220 mg of 2-(3,4-diethoxyphenyl)-5,6-dihydrothiazolo[4,5-d]pyridazine-4,7-dione.

출처